The basis analysis of indicators of development and use of human resources in Lugansk area is carried out and methodical approaches concerning the analysis and forecasting, development potential of the population, region with use of information possibilities of the state statistical reporting are offered. The total results and prognosis: the reduction of the constant regional population mostly in a country region and of the key branches which use the employed workers at the enterprises, organizations and institutions working in a «shady» economy shows clearly the mistaken social and economic policy undertaken in Ukraine and its component parts (social, demographic, tax, financial and crediting, investment, enterprising and others) at a regional level.