Elaboration the instruments of the regulation and the impact on the labor potential is particularly relevant in the context of administrative and territorial reform. New challenges will be posed to regional authorities, which should be required to provide scientifcally grounded sustainable human development in different areas. The purpose of the study is to identify the features of reproduction processes associated with labor potential in priority economic activities of Zakarpattya region and to establish the perspective policy directions for their improvement. To achieve this goal the following methods of research were applied: economic and statistical analysis, synthesis, expert surveys, causal relationships, grouping. Characteristics of the labor potential reproduction in priority economic activities of Zakarpattya region (agriculture, forestry and logging, production of food, beverages and tobacco products, woodworking, engineering, tourism) are researched in the article. Authors analyzed the main parameters and conditions of formation, distribution, realization and preservation of labor potential in priority regional economic activities in the following areas: number of employees; age structure; the fuidity of companies’ human resources; educational level of employees; system of vocational education and training for economic activities; companies’ activity of human resources development; salary level; labor productivity; correlation between changes in real wages and labor productivity; working conditions; sectoral factors of strongest infuence on the number of employees; the businesses’ assessment the problems with the formation training and learning of human resources. Analysis of these components was based on: data of statistics agencies for 2005-2013 years; expert survey conducted in November and December 2013 in all districts and cities of regional importance of Zakarpattya region among businesses of priority economic activities, local authorities and nongovernmental organizations; research of the educational system. The main results of the study demonstrated that: the number of employees is reducing but productivity is increasing; working conditions are improving; level of staff turnover is high; educational level of employees is still despite its’ improving; there are no stable trends towards rejuvenation of personnel; salary level is raising but remains below the average in the region; activity of enterprises to develop the employment potential is low. The article outlines recommendations for improving regional policy of labor potential development.