The process of genetics-evolution transformation of institutional matrix of the regions of Ukraine has been considered. Found out reasons of canning of not effective of regional institutes. On the basis of kilometric analysis position of institutional theory has been developed in relation to dependence of vectors of institutional transformation on the previous way of institutional development. Outlined subsequent way of development of institutional environment of domestic regions and prospect of increase of scales institutional «to the break» between the regions of Ukraine and EU. Grounded a necessity of the use of adaptive-pragmatic model of regional institutional policy is in the process of institutionalization of norms and rules of conduct of economic subjects in the conditions of European integration. 

institutionalization, institutional matrix, regional institutes