The implementation of Ukraine's chosen course of authorities’ decentralization contains certain problems, challenges, and even threats that should be taken into account when implementing this strategy in the institutional body of the state, as well as in implementing the state map of productive forces modernization. The purpose of the article is to determine the essence of the concept of methodological strategizing of regional development in the conditions of Ukraine’s institutional base modernization. The article analyzes the main methodological aspects of modernization of the institutional basis of regional development, identifies formal and informal rules, patterns, maxims, factors, methods and vectors of institutional core formation, areas for improving the regulatory framework and civil society development. The essence of the concept of methodological strategizing of regional development in the conditions of Ukraine’s institutional base modernization is determined. The contradictions in the normative-legal base concerning the administrative-territorial structure, formation, and functioning of spatial economic formations on the basis of sustainability, establishment of efficient territorial management by local executive bodies and united territorial communities are emphasized. The modernization of the institutional basis of regional development in the context of authorities’ decentralization is confirmed to be also influenced by various factors that impact the efficiency of the implementation of the national inclusive sustainable development strategy. As a result of the research, the author's vision of the essence of methodological strategizing of regional development, which absolutely needs modernization of the institutional base of state formation, is outlined. The authors point out that the immediate standardization of the strategic course for the authorities’ decentralization in the Constitution of Ukraine should be the priority step in correcting the mistakes and the need for an institutional definition with the rights, responsibilities, and structure of local executive bodies. 

institutional core, modernization of institutional base, regional development, localization of economic space, authorities’ decentralization, development of productive forces