The progress of digital technologies opens new opportunities for economic growth in general and the intensification of industrial production in particular. Issues directly related to the digitalization of industry are now on the agenda of reputable international organizations, national governments, and business representatives, and are at the center of attention of the scientific community. Studies of the phenomenon of industry digitalization are especially important for Ukraine, whose industrial sector has been in decline for a long time. The paper within the framework of a multilevel structural-functional approach highlights the essence, main advantages and problematic aspects of digitalization of industrial systems at local, regional and national levels, as well as highlights the key factors of successful modernization of the processes of design, production and consumption of industrial products under the influence of the involvement of information and digital technologies. The paper argues that the speed and success of the “digital transition” of industrial enterprises depend not only on the existing conditions for accelerated development of technological innovations or the formation of “road maps” of digitalization of certain industries or regions but also on the behavior of companies, their competitors and consumers of their products. The directions of modernization of the management system of industrial development in the conditions of the Ukrainian realities are considered. A matrix structure of program tasks to support the digitalization of the region’s industrial system is proposed. It will allow coordination of the activities of public authorities, local governments, research and educational institutions, businesses and NGOs to support measures for the digitalization of the region’s industrial system, and generate and adsorb relevant innovations. Widespread use of benchmarking methods is proposed for the successful digitalization of industrial systems at the local level. 

industrial systems, digitalization, Industry 4.0, multilevel structural-functional approach, management levels, regional programs