Since the 2020s, the strategic imperative and main competitive advantage for socio-economic systems has been to build resilience to unstable changes (shocks) in the external environment associated with global economic crises, natural and man-made disasters (disappearance of global biodiversity, climate change, increasing environmental pollution, natural disasters), global institutional economic and political transformations (decisions), political and ideological crises, technological and innovative breakthroughs, diplomatic confrontations, wars, pandemics, etc. The purpose of the article is to substantiate the concept of endogenous capacity of a region as a dominant factor in the formation of its resilient socio-economic system. The main factors and prerequisites for the formation of endogenous capacity of a region as a dominant factor in ensuring a resilient socio-economic system of the region are identified. The endogenous capacity for the formation of a resilient socio-economic system of the region is defined as the totality of the region’s internal potentials (human, natural, financial, institutional, social) that ensure its ability to develop independently and adapt in conditions of instability and change. Specifically, it is determined that endogenous capacity is characterized by the ability to recover and reorient after the impact of external global crises and challenges through internal adaptive drivers and internal socio-economic, institutional, and transformational potential of the region, which ensures the protection and structural renewal of the characteristics of the region’s socio-economic system in order to increase its ability to withstand negative influences, minimize losses, recover and transform quickly, while maintaining economic dynamics and social cohesion. Particular attention is paid to the factors of targeted endogenization of regional development in Ukraine, the priorities of increasing the endogenous potential of the socio-economic system from the perspective of ensuring an active frontal innovation policy, improving national ecogenetics, economic stability, and security based on the national roots of economic development. 

region, endogenous capacity of the region, internal potential of the region, resilient socio-economic system, endogenous development